deskgameTwo usually strong offenses go at it on Sunday Night Football, but the 49ers (5-6) continue to struggle as injuries have taken their toll. The Bills (9-2) still have hopes of securing the No. 1 seed in the AFC playoffs.
deskgameMahomes has passed for 260+ yards in each of his last three games. He has passed for 15 TDs in seven career starts against the Bills. Mahomes will get JuJu Smith-Schuster back from a hamstring injury this week to pair with new top WR DeAndre Hopkins.
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