deskgameDefense will be a point of emphasis for both teams, as the Eagles' secondary has allowed the third-fewest passing yards this season. Jayden Daniels has been less productive through the air since his injury against Carolina, so going under this mark seems likely on a short week.
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deskgameTwo usually strong offenses go at it on Sunday Night Football, but the 49ers (5-6) continue to struggle as injuries have taken their toll. The Bills (9-2) still have hopes of securing the No. 1 seed in the AFC playoffs.
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